The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb

The processing of amyloid precursor protein (APP) into β-amyloid peptide (Aβ) is a key step in the pathogenesis of Alzheimer’s disease (AD), and trafficking dysregulations of APP and its secretases contribute significantly to altered APP processing. Here we show that the cell polarity protein Par3 p...

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Detalles Bibliográficos

Autores principales:	Miao Sun, Suwaiba Z. Asghar, Huaye Zhang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2016-09-01
Colección:	Neurobiology of Disease
Materias:	Cell polarity Trafficking Alzheimer disease Amyloid precursor protein (APP) Amyloid-β (Aβ) Par3
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S0969996116300687
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