Molecular modeling and structural analysis of two-pore domain potassium channels TASK1 interactions with the blocker A1899
A1899 is a potent and highly selective blocker of the Two-pore domain potassium (K2P) channel TASK-1, it acts as an antagonist blocking the K+ flux and binds to TASK-1 in the inner cavity and shows an activity in nanomolar order. This drug travels through the central cavity and finally binds in the...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015-03-01
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| coleção: | Frontiers in Cellular Neuroscience |
| Assuntos: | |
| Acesso em linha: | http://journal.frontiersin.org/Journal/10.3389/conf.fncel.2015.35.00019/full |
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