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External signals regulate continuous transcriptional states in hematopoietic stem cells

Hematopoietic stem cells (HSCs) must ensure adequate blood cell production following distinct external stressors. A comprehensive understanding of in vivo heterogeneity and specificity of HSC responses to external stimuli is currently lacking. We performed single-cell RNA sequencing (scRNA-Seq) on f...

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Autori principali: Eva M Fast, Audrey Sporrij, Margot Manning, Edroaldo Lummertz Rocha, Song Yang, Yi Zhou, Jimin Guo, Ninib Baryawno, Nikolaos Barkas, David Scadden, Fernando Camargo, Leonard I Zon
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2021-12-01
Serie:eLife
Soggetti:
chromatin
stem cell niche
blood
interferons
prostaglandins
growth factors
Accesso online:https://elifesciences.org/articles/66512
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