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Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts

Abstract Histone lysine methylation is thought to play a role in the pathogenesis of rheumatoid arthritis (RA). We previously reported aberrant expression of the gene encoding mixed-lineage leukemia 1 (MLL1), which catalyzes methylation of histone H3 lysine 4 (H3K4), in RA synovial fibroblasts (SFs)...

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Principais autores: Keita Okamoto, Yasuto Araki, Yoshimi Aizaki, Shinya Tanaka, Yuho Kadono, Toshihide Mimura
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-05-01
Serier:Scientific Reports
Fag:
Rheumatoid arthritis
Synovial fibroblast
Histone lysine methylation
Cytokine
Chemokine
Online adgang:https://doi.org/10.1038/s41598-024-60860-7
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