Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts

Abstract Histone lysine methylation is thought to play a role in the pathogenesis of rheumatoid arthritis (RA). We previously reported aberrant expression of the gene encoding mixed-lineage leukemia 1 (MLL1), which catalyzes methylation of histone H3 lysine 4 (H3K4), in RA synovial fibroblasts (SFs)...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Keita Okamoto, Yasuto Araki, Yoshimi Aizaki, Shinya Tanaka, Yuho Kadono, Toshihide Mimura
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2024-05-01
Rangatū:	Scientific Reports
Ngā marau:	Rheumatoid arthritis Synovial fibroblast Histone lysine methylation Cytokine Chemokine
Urunga tuihono:	https://doi.org/10.1038/s41598-024-60860-7
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!