Tight Binding of Plasmid DNA With Self-Assembled Tetramethylguanidinium Conjugated Polyethylenimine Suppresses Transfection Efficiency

Here, we have demonstrated that on modification of linear polyethylenimine (lPEI, LP) with amphiphilic 3-bromopropyltetramethylguanidinium (PTMG) linker, the transfection efficiency exhibited by the modified polymers decreased while cell viability improved. A series of LP-PTMG polymers was synthesiz...

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Detalhes bibliográficos

Principais autores:	Santosh Yadav, Ashwani Kumar Sharma, Pradeep Kumar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-06-01
coleção:	Frontiers in Nanotechnology
Assuntos:	Gene delivery cytotoxicity Nanoparticles polyethylenimine Self-assembly
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnano.2021.674360/full
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