Extracellular vesicles from mesenchymal stem cells improve neuroinflammation and neurotransmission in hippocampus and cognitive impairment in rats with mild liver damage and minimal hepatic encephalopathy

Abstract Background Patients with steatotic liver disease may show mild cognitive impairment. Rats with mild liver damage reproduce this cognitive impairment, which is mediated by neuroinflammation that alters glutamate neurotransmission in the hippocampus. Treatment with extracellular vesicles (EV)...

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Principais autores:	Gergana Mincheva, Victoria Moreno-Manzano, Vicente Felipo, Marta Llansola
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-12-01
coleção:	Stem Cell Research & Therapy
Assuntos:	Mild liver damage Extracellular vesicles TGFβ Cognitive impairment Glial activation GABA and glutamate receptors
Acesso em linha:	https://doi.org/10.1186/s13287-024-04076-6
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