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SP1-induced upregulation of lncRNA SPRY4-IT1 exerts oncogenic properties by scaffolding EZH2/LSD1/DNMT1 and sponging miR-101-3p in cholangiocarcinoma

Abstract Background Accumulating evidence has indicated that long non-coding RNAs (lncRNAs) behave as a novel class of transcription products during multiple cancer processes. However, the mechanisms responsible for their alteration in cholangiocarcinoma (CCA) are not fully understood. Methods The e...

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Principais autores: Yi Xu, Yue Yao, Xingming Jiang, Xiangyu Zhong, Zhidong Wang, Chunlong Li, Pengcheng Kang, Kaiming Leng, Daolin Ji, Zhenglong Li, Lining Huang, Wei Qin, Yunfu Cui
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-04-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
Cholangiocarcinoma
lncRNA
SPRY4-IT1
Scaffold
Oncogenic properties
Online adgang:http://link.springer.com/article/10.1186/s13046-018-0747-x
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