Ageing-associated long non-coding RNA extends lifespan and reduces translation in non-dividing cells

Abstract Genomes produce widespread long non-coding RNAs (lncRNAs) of largely unknown functions. We characterize aal1 (ageing-associated lncRNA), which is induced in quiescent fission yeast cells. Deletion of aal1 shortens the chronological lifespan of non-dividing cells, while ectopic overexpressio...

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Detalles Bibliográficos

Principais autores:	Shajahan Anver, Ahmed Faisal Sumit, Xi-Ming Sun, Abubakar Hatimy, Konstantinos Thalassinos, Samuel Marguerat, Nazif Alic, Jürg Bähler
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer Nature 2024-10-01
Series:	EMBO Reports
Assuntos:	Protein Translation Chronological Lifespan Schizosaccharomyces pombe Ribosomal Protein RNA Regulation
Acceso en liña:	https://doi.org/10.1038/s44319-024-00265-9
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