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Combination Regimens of Favipiravir Plus Interferon Alpha Inhibit Chikungunya Virus Replication in Clinically Relevant Human Cell Lines

Chikungunya virus (CHIKV) is an alphavirus associated with a broad tissue tropism for which no antivirals or vaccines are approved. This study evaluated the antiviral potential of favipiravir (FAV), interferon-alpha (IFN), and ribavirin (RBV) against CHIKV as mono- and combination-therapy in cell li...

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Principais autores: Evelyn J. Franco, Xun Tao, Kaley C. Hanrahan, Jieqiang Zhou, Jürgen B. Bulitta, Ashley N. Brown
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-02-01
Serier:Microorganisms
Fag:
chikungunya virus
favipiravir
interferon-alpha
combination therapy
mathematical modeling
Online adgang:https://www.mdpi.com/2076-2607/9/2/307
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