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Filarial Lymphedema Patients Are Characterized by Exhausted CD4+ T Cells

Worldwide, more than 200 million people are infected with filariae which can cause severe symptoms leading to reduced quality of life and contribute to disability-adjusted life years (DALYs). In particular, lymphatic filariasis (LF) caused by Wuchereria bancrofti can lead to lymphedema (LE) and cons...

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Uloženo v:
Hlavní autoři: Sacha Horn, Manuel Ritter, Kathrin Arndts, Dennis Borrero-Wolff, Anna Wiszniewsky, Linda Batsa Debrah, Alexander Y. Debrah, Jubin Osei-Mensah, Mkunde Chachage, Achim Hoerauf, Inge Kroidl, Laura E. Layland
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2022-01-01
Edice:Frontiers in Cellular and Infection Microbiology
Témata:
filariae
CD4+ T cell exhaustion
Wuchereria bancrofti infection
lymphatic filariasis
immune modulation
lymphedema
On-line přístup:https://www.frontiersin.org/articles/10.3389/fcimb.2021.767306/full
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