Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes

The inflammasome is an intracellular multi-protein complex that orchestrates the release of the pro-inflammatory cytokines IL-1β and IL-18, and a form of cell death known as pyroptosis. Tyrosine phosphorylation of the inflammasome sensors NLRP3, AIM2, NLRC4, and the adaptor protein, apoptosis-associ...

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Autori principali:	Bezaleel Mambwe, Kurt Neo, Hanif Javanmard Khameneh, Keith Weng Kit Leong, Mariasilvia Colantuoni, Maurizio Vacca, Richmond Muimo, Alessandra Mortellaro
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2019-07-01
Serie:	Frontiers in Immunology
Soggetti:	inflammasome activation NLRP3 ASC tyrosine dephosphorylation tyrosine phosphorylation
Accesso online:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01556/full
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