Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases

Abstract Background Dysregulated activation of the inflammasome is involved in various human diseases including acute cerebral ischemia, multiple sclerosis and sepsis. Though many inflammasome inhibitors targeting NOD-like receptor protein 3 (NLRP3) have been designed and developed, none of the inhi...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Chen Chen, YuWei Zhou, XinPeng Ning, ShengLong Li, DongDong Xue, CaiLv Wei, Zhu Zhu, LongXiang Sheng, BingZheng Lu, Yuan Li, XiaoYuan Ye, YunZhao Fu, Chuan Bai, Wei Cai, YuXuan Ding, SuiZhen Lin, GuangMei Yan, YiJun Huang, Wei Yin
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2022-12-01
Σειρά:	Journal of Neuroinflammation
Θέματα:	ASC inhibitors Inflammasome Lonidamine Multiple sclerosis Ischemic stroke Sepsis
Διαθέσιμο Online:	https://doi.org/10.1186/s12974-022-02682-w
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