Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program

Abstract To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs]. We conduct a cross-sectional study of the associat...

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Autors principals:	Chloé Sarnowski, Yixin Zhang, Farah Ammous, Lincoln M. P. Shade, Daniel DiCorpo, Xueqiu Jian, Donna K. Arnett, Thomas R. Austin, Alexa Beiser, Joshua C. Bis, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E. Curran, Charles S. DeCarli, Harsha Doddapaneni, Josée Dupuis, David W. Fardo, Jose C. Florez, Stacey Gabriel, Richard A. Gibbs, David C. Glahn, Namrata Gupta, Hector M. González, Kevin A. González, Konstantinos Hatzikotoulas, Kathleen M. Hayden, Susan R. Heckbert, Bertha Hidalgo, Alicia Huerta-Chagoya, Timothy M. Hughes, Sharon L. R. Kardia, Charles L. Kooperberg, Lenore J. Launer, W. T. Longstreth, T2DGGI consortium, MAGIC consortium, Ravi Mandla, Rasika A. Mathias, Andrew P. Morris, Thomas H. Mosley, Ilya M. Nasrallah, Paul Nyquist, Bruce M. Psaty, Qibin Qi, Laura M. Raffield, Nigel W. Rayner, Alexander P. Reiner, Claudia L. Satizabal, Elizabeth Selvin, Magdalena D. R. Sevilla-Gonzalez, Albert V. Smith, Jennifer A. Smith, Kirk Smith, Beverly M. Snively, Lorraine Southam, Tamar Sofer, Ken Suzuki, Henry J. Taylor, Miriam S. Udler, Karine A. Viaud-Martinez, Sylvia Wassertheil-Smoller, Alexis C. Wood, Lisa R. Yanek, Xianyong Yin, Alisa K. Manning, Jerome I. Rotter, Stephen S. Rich, James B. Meigs, Myriam Fornage, Sudha Seshadri, Alanna C. Morrison, On behalf of the TOPMed Diabetes working group, and the TOPMed Neurocognitive working group
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-09-01
Col·lecció:	Communications Biology
Accés en línia:	https://doi.org/10.1038/s42003-025-08674-9
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