Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program

Abstract To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs]. We conduct a cross-sectional study of the associat...

முழு விளக்கம்

நூற்பட்டியல் விவரங்கள்

முதன்மை ஆசிரியர்கள்:	Chloé Sarnowski, Yixin Zhang, Farah Ammous, Lincoln M. P. Shade, Daniel DiCorpo, Xueqiu Jian, Donna K. Arnett, Thomas R. Austin, Alexa Beiser, Joshua C. Bis, John Blangero, Eric Boerwinkle, Jan Bressler, Joanne E. Curran, Charles S. DeCarli, Harsha Doddapaneni, Josée Dupuis, David W. Fardo, Jose C. Florez, Stacey Gabriel, Richard A. Gibbs, David C. Glahn, Namrata Gupta, Hector M. González, Kevin A. González, Konstantinos Hatzikotoulas, Kathleen M. Hayden, Susan R. Heckbert, Bertha Hidalgo, Alicia Huerta-Chagoya, Timothy M. Hughes, Sharon L. R. Kardia, Charles L. Kooperberg, Lenore J. Launer, W. T. Longstreth, T2DGGI consortium, MAGIC consortium, Ravi Mandla, Rasika A. Mathias, Andrew P. Morris, Thomas H. Mosley, Ilya M. Nasrallah, Paul Nyquist, Bruce M. Psaty, Qibin Qi, Laura M. Raffield, Nigel W. Rayner, Alexander P. Reiner, Claudia L. Satizabal, Elizabeth Selvin, Magdalena D. R. Sevilla-Gonzalez, Albert V. Smith, Jennifer A. Smith, Kirk Smith, Beverly M. Snively, Lorraine Southam, Tamar Sofer, Ken Suzuki, Henry J. Taylor, Miriam S. Udler, Karine A. Viaud-Martinez, Sylvia Wassertheil-Smoller, Alexis C. Wood, Lisa R. Yanek, Xianyong Yin, Alisa K. Manning, Jerome I. Rotter, Stephen S. Rich, James B. Meigs, Myriam Fornage, Sudha Seshadri, Alanna C. Morrison, On behalf of the TOPMed Diabetes working group, and the TOPMed Neurocognitive working group
வடிவம்:	Artigo
மொழி:	Inglês
வெளியிடப்பட்டது:	Nature Portfolio 2025-09-01
தொடர்:	Communications Biology
ஆன்லைன் அணுகல்:	https://doi.org/10.1038/s42003-025-08674-9
குறிச்சொற்கள்:	குறிச்சொல்லை சேர்க்கவும் டாக்‌ஸ் இல்லை, இந்த பதிவுக்கு குறிச்சொல் சேர்க்கும் முதல் நபராக இருங்கள்!