STAT-3 is necessary for IL-27-mediated macrophage suppression but does not represent a therapeutic target for E. coli-induced neonatal sepsis

ABSTRACT Interleukin (IL)-27 is a heterodimeric immunoregulatory cytokine expressed at elevated levels early in life that compromises bacterial clearance and promotes severe outcomes during neonatal sepsis. In turn, IL-27Rα-deficient neonatal mice exhibit better control of bacteria, reduced systemic...

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Hlavní autoři:	Madhavi Annamanedi, Jessica M. Povroznik, Cory M. Robinson
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2025-05-01
Edice:	Microbiology Spectrum
Témata:	interleukin-27 neonatal sepsis STAT-3 lysosome bacteria inflammation
On-line přístup:	https://journals.asm.org/doi/10.1128/spectrum.02211-24
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