STAT-3 is necessary for IL-27-mediated macrophage suppression but does not represent a therapeutic target for E. coli-induced neonatal sepsis

ABSTRACT Interleukin (IL)-27 is a heterodimeric immunoregulatory cytokine expressed at elevated levels early in life that compromises bacterial clearance and promotes severe outcomes during neonatal sepsis. In turn, IL-27Rα-deficient neonatal mice exhibit better control of bacteria, reduced systemic...

Olles dieđut

Bibliográfalaš dieđut

Váldodahkkit:	Madhavi Annamanedi, Jessica M. Povroznik, Cory M. Robinson
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Microbiology 2025-05-01
Ráidu:	Microbiology Spectrum
Fáttát:	interleukin-27 neonatal sepsis STAT-3 lysosome bacteria inflammation
Liŋkkat:	https://journals.asm.org/doi/10.1128/spectrum.02211-24
Fáddágilkorat:	Lasit fáddágilkoriid Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!