Transcriptomic Analysis Reveals an NRF2-Mediated Redox and Metabolic Reprogramming in Sorafenib-Resistant Hepatocellular Carcinoma Cells

Despite the advent of immune checkpoint inhibitor-based regimens, sorafenib remains an important therapeutic option for patients with advanced hepatocellular carcinoma (HCC) who are ineligible for immunotherapy. However, its clinical efficacy is limited by the emergence of drug resistance, whose und...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Angelo Michilli, Cristian Bassi, Farzaneh Moshiri, Bruno De Siena, Rosaria Marinaro, Elisa Callegari, Massimo Negrini, Silvia Sabbioni
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	MDPI AG 2026-02-01
Sarja:	BioTech
Aiheet:	hepatocellular carcinoma sorafenib resistance NRF2 redox metabolism oxidative stress transcriptomics
Linkit:	https://www.mdpi.com/2673-6284/15/1/18
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