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Transcriptomic Analysis Reveals an NRF2-Mediated Redox and Metabolic Reprogramming in Sorafenib-Resistant Hepatocellular Carcinoma Cells

Despite the advent of immune checkpoint inhibitor-based regimens, sorafenib remains an important therapeutic option for patients with advanced hepatocellular carcinoma (HCC) who are ineligible for immunotherapy. However, its clinical efficacy is limited by the emergence of drug resistance, whose und...

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Principais autores: Angelo Michilli, Cristian Bassi, Farzaneh Moshiri, Bruno De Siena, Rosaria Marinaro, Elisa Callegari, Massimo Negrini, Silvia Sabbioni
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2026-02-01
סדרה:BioTech
נושאים:
hepatocellular carcinoma
sorafenib resistance
NRF2
redox metabolism
oxidative stress
transcriptomics
גישה מקוונת:https://www.mdpi.com/2673-6284/15/1/18
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