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Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway

Mutations in PHF8 gene are genetically associated with X-linked mental retardation. Here, Chen et al. show that Phf8 KO mouse have cognitive and synaptic plasticity impairment, and pharmacological inhibition of mTOR signaling can partially alleviate such defects.

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Principais autores: Xuemei Chen, Shuai Wang, Ying Zhou, Yanfei Han, Shengtian Li, Qing Xu, Longyong Xu, Ziqi Zhu, Youming Deng, Lu Yu, Lulu Song, Adele Pin Chen, Juan Song, Eiki Takahashi, Guang He, Lin He, Weidong Li, Charlie Degui Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2018-01-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-017-02531-y
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