SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A

The histone demethylase JMJD2A/KDM4A facilitates prostate cancer development, yet how JMJD2A function is regulated has remained elusive. Here, we demonstrate that SET7/9-mediated methylation on 6 lysine residues modulated JMJD2A. Joint mutation of these lysine residues suppressed JMJD2A’s ability to...

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Detalhes bibliográficos

Principais autores:	Ruicai Gu, Tae-Dong Kim, Hoogeun Song, Yuan Sui, Sook Shin, Sangphil Oh, Ralf Janknecht
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical investigation 2023-10-01
coleção:	JCI Insight
Assuntos:	Cell biology Oncology
Acesso em linha:	https://doi.org/10.1172/jci.insight.164990
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