Docking and stability defects in mitofusin highlight the proteasome as a potential therapeutic target
Summary: Defects in mitochondrial fusion are at the base of many diseases. Mitofusins power membrane-remodeling events via self-interaction and GTP hydrolysis. However, how exactly mitofusins mediate fusion of the outer membrane is still unclear. Structural studies enable tailored design of mitofusi...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2023-07-01
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| Serie: | iScience |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S258900422301091X |
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