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A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide

N-Acetylgalactosamine (GalNAc) is an efficient and multifunctional delivery tool in the development and synthesis of chemically modified oligonucleotide therapeutics (conjugates). Such therapeutics demonstrate improved potency in vivo due to the selective and efficient delivery to hepatocytes in the...

Täydet tiedot

Tallennettuna:
Päätekijät: Artem Evgenievich Gusev, Vladimir Nikolaevich Ivanov, Nikolai Andreevich Dmitriev, Aleksandr Viktorovich Kholstov, Vladislav Aleksandrovich Vasilichin, Ilya Andreevich Kofiadi, Musa Rakhimovich Khaitov
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2024-12-01
Sarja:Molecules
Aiheet:
oligonucleotides
phosphoramidite
GalNAc
N-acetylgalactosamine
siRNA
L96
Linkit:https://www.mdpi.com/1420-3049/29/24/5959
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