Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways

Summary: Increased blood amino acid levels (hyperaminoacidemia) stimulate pancreas expansion by unclear mechanisms. Here, by genetic and pharmacological disruption of glucagon receptor (GCGR) in mice and zebrafish, we found that the ensuing hyperaminoacidemia promotes pancreatic acinar cell prolifer...

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Автори:	Chunhua Dai, Yue Zhang, Yulong Gong, Amber Bradley, Zihan Tang, Katelyn Sellick, Shristi Shrestha, Erick Spears, Brittney A. Covington, Jade Stanley, Regina Jenkins, Tiffany M. Richardson, Rebekah A. Brantley, Katie Coate, Diane C. Saunders, Jordan J. Wright, Marcela Brissova, E. Danielle Dean, Alvin C. Powers, Wenbiao Chen
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Elsevier 2024-12-01
Серія:	iScience
Предмети:	Biomolecules Molecular biology Cell biology Model organism
Онлайн доступ:	http://www.sciencedirect.com/science/article/pii/S2589004224026749
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Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways

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