Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways

Summary: Increased blood amino acid levels (hyperaminoacidemia) stimulate pancreas expansion by unclear mechanisms. Here, by genetic and pharmacological disruption of glucagon receptor (GCGR) in mice and zebrafish, we found that the ensuing hyperaminoacidemia promotes pancreatic acinar cell prolifer...

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Detalhes bibliográficos

Principais autores:	Chunhua Dai, Yue Zhang, Yulong Gong, Amber Bradley, Zihan Tang, Katelyn Sellick, Shristi Shrestha, Erick Spears, Brittney A. Covington, Jade Stanley, Regina Jenkins, Tiffany M. Richardson, Rebekah A. Brantley, Katie Coate, Diane C. Saunders, Jordan J. Wright, Marcela Brissova, E. Danielle Dean, Alvin C. Powers, Wenbiao Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-12-01
coleção:	iScience
Assuntos:	Biomolecules Molecular biology Cell biology Model organism
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004224026749
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