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Elucidation of the binding interaction interface between AAV serotype 11 capsid protein and host nuclear import proteins

Adeno-associated viruses (AAVs) are widely acknowledged as versatile vectors for gene therapy due to their non-pathogenic nature, inherent capacity for tissue-specific targeting, and their potential for customizable engineering. The N terminus of the AAV capsid protein VP1 plays a pivotal role in gu...

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Principais autores: Mikayla Hoad, Sepehr Nematollahzadeh, Justin A. Roby, Gualtiero Alvisi, Jade K. Forwood
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2025-12-01
Series:Molecular Therapy: Methods & Clinical Development
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Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2329050125002256
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