Bortezomib-based antibody depletion for refractory autoimmune hematological diseases

Abstract: Certain patients with antibody-mediated autoimmune disease exhibit poor responses to conventional immunosuppression, including B-cell depletion with rituximab. Proteasome inhibitors such as bortezomib demonstrate pleiotropic immunomodulatory effects, including direct toxicity to antibody-p...

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Главные авторы:	Sumita Ratnasingam, Patricia A. Walker, Huy Tran, Zane S. Kaplan, James D. McFadyen, Huyen Tran, Tse-Chieh Teh, Shaun Fleming, John V. Catalano, Sanjeev D. Chunilal, Anna Johnston, Stephen S. Opat, Jake Shortt
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2016-11-01
Серии:	Blood Advances
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2473952920303670
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