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Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species

Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it. Consequently, converting FLC into a fungicidal agent using adjuvants assumes s...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Wanqian Li, Yanru Feng, Zhe Feng, Li Wang, Malcolm Whiteway, Hui Lu, Yuanying Jiang
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2024-05-01
Schriftenreihe:Antioxidants
Schlagworte:
pitavastatin calcium
fluconazole tolerance
ubiquinone biosynthesis
reactive oxygen species
<i>Candida albicans</i>
Online-Zugang:https://www.mdpi.com/2076-3921/13/6/667
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