Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species

Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it. Consequently, converting FLC into a fungicidal agent using adjuvants assumes s...

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Hlavní autoři:	Wanqian Li, Yanru Feng, Zhe Feng, Li Wang, Malcolm Whiteway, Hui Lu, Yuanying Jiang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2024-05-01
Edice:	Antioxidants
Témata:	pitavastatin calcium fluconazole tolerance ubiquinone biosynthesis reactive oxygen species <i>Candida albicans</i>
On-line přístup:	https://www.mdpi.com/2076-3921/13/6/667
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