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Untargeted metabolomics reveals distinct biomarkers and metabolic alterations in familial and non-genetic hypercholesterolemia in Saudi patients

BackgroundFamilial hypercholesterolemia (FH) and non-genetic hypercholesterolemia (HC) are both associated with elevated low-density cholesterol (LDL-C) levels, which increase the risk of cardiovascular disease. However, their underlying metabolic disturbances differ significantly. Untargeted metabo...

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Principais autores: Hadiah Bassam Al Mahdi, Noor Ahmad Shaik, Zuhier Awan, Hussam Daghistani, Faisal Alandejani, Kawthar Saad Alghamdi, Ahmad A. Obaid, Rawabi Zahed, Reem Nabil Hassan, Sherif Edris, Babajan Banaganapalli, Abdulrahman Mujalli
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-09-01
coleção:Frontiers in Medicine
Assuntos:
familial hypercholesterolemia
untargeted metabolomics
KEGG database
biomarkers
cholic acid
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmed.2025.1670282/full
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