Untargeted metabolomics reveals distinct biomarkers and metabolic alterations in familial and non-genetic hypercholesterolemia in Saudi patients

BackgroundFamilial hypercholesterolemia (FH) and non-genetic hypercholesterolemia (HC) are both associated with elevated low-density cholesterol (LDL-C) levels, which increase the risk of cardiovascular disease. However, their underlying metabolic disturbances differ significantly. Untargeted metabo...

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Hlavní autoři:	Hadiah Bassam Al Mahdi, Noor Ahmad Shaik, Zuhier Awan, Hussam Daghistani, Faisal Alandejani, Kawthar Saad Alghamdi, Ahmad A. Obaid, Rawabi Zahed, Reem Nabil Hassan, Sherif Edris, Babajan Banaganapalli, Abdulrahman Mujalli
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-09-01
Edice:	Frontiers in Medicine
Témata:	familial hypercholesterolemia untargeted metabolomics KEGG database biomarkers cholic acid
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmed.2025.1670282/full
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