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Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes.

Difficulties with inducing sterile and long lasting protective immunity against malaria with subunit vaccines has renewed interest in vaccinations with attenuated Plasmodium parasites. Immunizations with sporozoites that are attenuated by radiation (RAS) can induce strong protective immunity both in...

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Principais autores: Ben C L van Schaijk, Chris J Janse, Geert-Jan van Gemert, Melissa R van Dijk, Audrey Gego, Jean-Francois Franetich, Marga van de Vegte-Bolmer, Samir Yalaoui, Olivier Silvie, Stephen L Hoffman, Andrew P Waters, Dominique Mazier, Robert W Sauerwein, Shahid M Khan
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2008-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC2568858?pdf=render
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