Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes

Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected from phage libraries. The 2E7 group binds to a new line...

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Detalhes bibliográficos

Principais autores:	Nika M. Strokappe, Miriam Hock, Lucy Rutten, Laura E. Mccoy, Jaap W. Back, Christophe Caillat, Matthias Haffke, Robin A. Weiss, Winfried Weissenhorn, Theo Verrips
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-06-01
coleção:	Antibodies
Assuntos:	Aids HIV Llama Antibodies bi-specific VHH pepscan competition studies epitope mapping co-crystallisation
Acesso em linha:	https://www.mdpi.com/2073-4468/8/2/38
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