Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes

Broad and potent neutralizing llama single domain antibodies (VHH) against HIV-1 targeting the CD4 binding site (CD4bs) have previously been isolated upon llama immunization. Here we describe the epitopes of three additional VHH groups selected from phage libraries. The 2E7 group binds to a new line...

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Bibliográfalaš dieđut

Váldodahkkit:	Nika M. Strokappe, Miriam Hock, Lucy Rutten, Laura E. Mccoy, Jaap W. Back, Christophe Caillat, Matthias Haffke, Robin A. Weiss, Winfried Weissenhorn, Theo Verrips
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2019-06-01
Ráidu:	Antibodies
Fáttát:	Aids HIV Llama Antibodies bi-specific VHH pepscan competition studies epitope mapping co-crystallisation
Liŋkkat:	https://www.mdpi.com/2073-4468/8/2/38
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