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The effect of neo-adjuvant chemotherapy with 5-fluorouracil on the integrity of colonic anastomoses: a systematic review and meta-analysis of experimental studies on rats

Study designSystematic review and update meta-analysis.PurposeThis systematic review and meta-analysis was conducted to determine the effect of preoperative (neoadjuvant) chemotherapy with 5-fluorouracil (intraperitoneal) on the integrity of colorectal anastomoses in an experimental rat model.Overvi...

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Bibliographic Details
Main Authors: Tatiana Chernyshenko, Roman Polkin, Maksat Ashyrov, Valeriy Shepelev, Roman Goncharuk
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-03-01
Series:Frontiers in Surgery
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Online Access:https://www.frontiersin.org/articles/10.3389/fsurg.2026.1737152/full
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