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The effect of neo-adjuvant chemotherapy with 5-fluorouracil on the integrity of colonic anastomoses: a systematic review and meta-analysis of experimental studies on rats

Study designSystematic review and update meta-analysis.PurposeThis systematic review and meta-analysis was conducted to determine the effect of preoperative (neoadjuvant) chemotherapy with 5-fluorouracil (intraperitoneal) on the integrity of colorectal anastomoses in an experimental rat model.Overvi...

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Principais autores: Tatiana Chernyshenko, Roman Polkin, Maksat Ashyrov, Valeriy Shepelev, Roman Goncharuk
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2026-03-01
Series:Frontiers in Surgery
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Acceso en liña:https://www.frontiersin.org/articles/10.3389/fsurg.2026.1737152/full
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