Efficacy and safety of olezarsen in lowering apolipoprotein C-III and triglycerides in healthy Japanese Americans

Abstract Background Olezarsen is a GalNAc3-conjugated, hepatic-targeted antisense oligonucleotide that lowers apolipoprotein C-III (apoC-III) and triglyceride levels. The efficacy and safety of olezarsen has not previously been studied in ethnically diverse American populations. The aim of this stud...

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Hauptverfasser:	Ewa Karwatowska-Prokopczuk, Anastasia Lesogor, Jing-He Yan, Angelika Hoenlinger, Alison Margolskee, Lu Li, Sotirios Tsimikas
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-10-01
Schriftenreihe:	Lipids in Health and Disease
Schlagworte:	Triglycerides ApoC-III Ethnicity Antisense oligonucleotide Pancreatitis Cardiovascular disease
Online-Zugang:	https://doi.org/10.1186/s12944-024-02297-5
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