FKBP51 disrupts the insulin signaling pathway and impairs mitochondrial bioenergetics in HepG2 cells

Abstract FKBP51 reportedly antagonizes insulin signaling by reducing Akt activity, thus contributing to insulin resistance and weight gain. This has been well established in FKBP51 knock-out mice. However, the effects of FKBP51 overexpression and its associated mechanisms have not been explored in l...

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Prif Awduron:	Camila Donoso-Barraza, Melissa Díaz-Roblero, Carlos Sepúlveda, Anais Villegas-Bravo, Sandra A. Soto-Alarcón, Danitza Durán-Castillo, Valeska Castillo, Roberto Bravo-Sagua, Rodrigo Troncoso
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Portfolio 2026-02-01
Cyfres:	Scientific Reports
Pynciau:	FKBP51 Insulin resistance Mitochondria Mitochondrial function Hepatocytes
Mynediad Ar-lein:	https://doi.org/10.1038/s41598-026-40414-9
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