FKBP51 disrupts the insulin signaling pathway and impairs mitochondrial bioenergetics in HepG2 cells

Abstract FKBP51 reportedly antagonizes insulin signaling by reducing Akt activity, thus contributing to insulin resistance and weight gain. This has been well established in FKBP51 knock-out mice. However, the effects of FKBP51 overexpression and its associated mechanisms have not been explored in l...

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Principais autores:	Camila Donoso-Barraza, Melissa Díaz-Roblero, Carlos Sepúlveda, Anais Villegas-Bravo, Sandra A. Soto-Alarcón, Danitza Durán-Castillo, Valeska Castillo, Roberto Bravo-Sagua, Rodrigo Troncoso
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-02-01
Series:	Scientific Reports
Assuntos:	FKBP51 Insulin resistance Mitochondria Mitochondrial function Hepatocytes
Acceso en liña:	https://doi.org/10.1038/s41598-026-40414-9
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