Elucidation of the mechanism Underlying the promotion of ferroptosis and enhanced antitumor immunity by citrus polymethoxyflavones in CRC cells

BackgroundColon cancer is a prevalent condition with a high mortality rate on a global scale. Research has indicated that Citrus polymethoxyflavones (PMFs), a class of flavonoids found in Citrus, possess the potential to demonstrate anti-tumor efficacy. Ferroptosis a form of cell death that is depen...

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Auteurs principaux:	Yingying Duan, Yu Wu, Jiaqi Tian, Yuqin Yin, Zhongwen Yuan, Wenting Zhu, Suyue Zhou, Chen Li, Senling Feng
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2025-04-01
Collection:	Frontiers in Pharmacology
Sujets:	colon cancer citrus polymethoxyflavones ferroptosis PD-L1 antitumor immunity
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1571178/full
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