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Sirtuin Family Members Selectively Regulate Autophagy in Osteosarcoma and Mesothelioma Cells in Response to Cellular Stress

The class III NAD+ dependent deacetylases-sirtuins (SIRTs) link transcriptional regulation to DNA damage response and reactive oxygen species generation thereby modulating a wide range of cellular signaling pathways. Here, the contribution of SIRT1, SIRT3, and SIRT5 in the regulation of cellular fat...

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Principais autores: Richa Garva, Chutamas Thepmalee, Umpa Yasamut, Sangkab Sudsaward, Alice Guazzelli, Ramkumar Rajendran, Nopprarat Tongmuang, Sasiprapa Khunchai, Parisa Meysami, Thawornchai Limjindaporn, Pa-thai Yenchitsomanus, Luciano Mutti, Marija Krstic-Demonacos, Constantinos Demonacos
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-09-01
coleção:Frontiers in Oncology
Assuntos:
autophagy
transcription
sirtuins
beclin-1
LC3
mesothelioma
Acesso em linha:https://www.frontiersin.org/article/10.3389/fonc.2019.00949/full
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