Engineering extracellular vesicles to transiently permeabilize the blood–brain barrier

Abstract Background Drug delivery to the brain is challenging due to the restrict permeability of the blood brain barrier (BBB). Recent studies indicate that BBB permeability increases over time during physiological aging likely due to factors (including extracellular vesicles (EVs)) that exist in t...

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Главные авторы:	Francesca Tomatis, Susana Rosa, Susana Simões, Marta Barão, Carlos Jesus, João Novo, Emanuel Barth, Manja Marz, Lino Ferreira
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2024-12-01
Серии:	Journal of Nanobiotechnology
Предметы:	Extracellular vesicles Modulation MicroRNA Blood–brain barrier Microfluidic system Claudin 5
Online-ссылка:	https://doi.org/10.1186/s12951-024-03019-w
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