Engineering extracellular vesicles to transiently permeabilize the blood–brain barrier

Abstract Background Drug delivery to the brain is challenging due to the restrict permeability of the blood brain barrier (BBB). Recent studies indicate that BBB permeability increases over time during physiological aging likely due to factors (including extracellular vesicles (EVs)) that exist in t...

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Detalhes bibliográficos

Principais autores:	Francesca Tomatis, Susana Rosa, Susana Simões, Marta Barão, Carlos Jesus, João Novo, Emanuel Barth, Manja Marz, Lino Ferreira
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2024-12-01
coleção:	Journal of Nanobiotechnology
Assuntos:	Extracellular vesicles Modulation MicroRNA Blood–brain barrier Microfluidic system Claudin 5
Acesso em linha:	https://doi.org/10.1186/s12951-024-03019-w
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