Targeting folate cycle enhances effects of cancer immunotherapy by modulating myeloid-derived suppressor cells

Objective·To explore the regulatory mechanism of folate cycle metabolism in the immunosuppressive effect of myeloid derived suppressor cells (MDSCs). Methods·Bone marrow cells were isolated from C57BL/6 mice and cultured in RPMI 1640 medium supplemented with GM-CSF, G-CSF, and IL-6 to induce MDSCs i...

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Detalhes bibliográficos

Principais autores:	HE Rui, YAN Kepeng, WANG Jing
Formato:	Artigo
Idioma:	Chinês
Publicado em:	Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 2024-08-01
coleção:	Shanghai Jiaotong Daxue xuebao. Yixue ban
Assuntos:	myeloid-derived suppressor cells (MDSCs) folate cycle methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) pemetrexed cancer immunotherapy
Acesso em linha:	https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-8-1011.shtml
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