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MDSC: a new potential breakthrough in CAR-T therapy for solid tumors

Abstract Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in hematologic malignancies but has encountered challenges in effectively treating solid tumors. One major obstacle is the presence of the immunosuppressive tumor microenvironment (TME), which is mainly built by m...

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שמור ב:
Principais autores: Nada Mohamady Farouk Abdalsalam, Abdulrahman Ibrahim, Muhammad Auwal Saliu, Tzu-Ming Liu, Xiaochun Wan, Dehong Yan
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2024-12-01
סדרה:Cell Communication and Signaling
נושאים:
Chimeric antigen receptor T (CAR-T)
Myeloid-derived suppressor cells (MDSCs)
Tumor microenvironment (TME)
Solid tumor
גישה מקוונת:https://doi.org/10.1186/s12964-024-01995-y
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