Epigenetic agents, zebularine and valproic acid, inhibit the growth of the oral squamous cell carcinoma cell line HSC4 in vitro and in vivo

Abstract Objectives This study explored the potential of Zebularine (Zeb), a DNA methyltransferase inhibitor (DNMTi), and Valproic acid (Vpa), a histone deacetylase inhibitor (HDACi), as a combined treatment strategy for OSCC. Materials and methods OSCC cell lines, HSC4 (well-differentiated type) an...

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Bibliografische gegevens

Hoofdauteurs:	Shuhei Takahashi, Koki Yoshida, Durga Paudel, Tetsuro Morikawa, Osamu Uehara, Fumiya Harada, Dedy Ariwansa, Sarita Giri, Jun Sato, Hiroki Nagayasu, Yoshihiro Abiko
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Springer 2025-07-01
Reeks:	Discover Oncology
Onderwerpen:	Epigenetics Oral squamous cell carcinoma Valproic acid Zebularine
Online toegang:	https://doi.org/10.1007/s12672-025-02928-y
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