Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale

Background The mechanisms underlying human germ cell development and infertility remain largely unknown due to bioethical issues and the shortage of experimental materials. Therefore, an effective in vitro induction system of human primordial germ-like cells (hPGCLCs) from human pluripotent stem cel...

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Hauptverfasser:	Xiaoman Wang, Tingting Liao, Cong Wan, Xiaoyu Yang, Jiexiang Zhao, Rui Fu, Zhaokai Yao, Yaping Huang, Yujia Shi, Gang Chang, Yi Zheng, Fang Luo, Zhaoting Liu, Yu Wang, Xinliang Mao, Xiao-Yang Zhao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	PeerJ Inc. 2019-01-01
Schriftenreihe:	PeerJ
Schlagworte:	Human primordial germ-like cells Induction system Methylcellulose hESCs hiPSCs Embryoids
Online-Zugang:	https://peerj.com/articles/6143.pdf
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