Exploring the nucleus accumbens circuit and oxytocin therapy in a Sapap3 knockout mouse model of trichotillomania

Abstract Trichotillomania (TTM), an understudied psychiatric disorder, was investigated using Sapap3 knockout (KO) mice to elucidate nucleus accumbens (NAc) circuit dysfunction and oxytocin’s therapeutic potential. Under aversive conditions, KO mice exhibited TTM-like behavioral phenotypes compared...

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Main Authors: Yuan Wang, Jingjing Yu, Rui Ma, Yundong Chen, Shihao Lu, Jianqun Fang
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2025-08-01
Series:Scientific Reports
Assuntos:
Sapap3
Trichotillomania (TTM)
Nucleus accumbens (NAc)
Oxytocin treatment
Dopamine signaling pathway
Acceso en liña:https://doi.org/10.1038/s41598-025-14076-y
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