Multi-omics insights into immune tolerance at the maternal–fetal interface in recurrent pregnancy loss: mechanisms, integration challenges, and translational perspectives

Recurrent pregnancy loss (RPL) is a heterogeneous reproductive disorder in which dysregulation of maternal–fetal immune tolerance, aberrant decidual immune remodeling, and altered inflammasome signaling have been implicated within a complex multi-omics landscape. Multi-omics profiling (genomics, epi...

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Principais autores:	Mengqiu Shao, Yiting Zhang, Haixia Tang, Ze Zhou, Manyin Zhai, Xiaoyu Zhou, Xiaoyu Bi, Jiabao Liao, Caiyan Zhang, Lijuan Jiang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-04-01
Series:	Frontiers in Immunology
Assuntos:	biomarker discovery decidual immune microenvironment immune dysregulation maternal–fetal immune tolerance multi-omics recurrent pregnancy loss
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1811970/full
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