Creating a more strategic small molecule biophysical hit characterization workflow

To confirm target engagement of hits from our high-throughput screening efforts, we ran biophysical assays on several hundreds of hits from 15 different high-throughput screening campaigns. Analyzing the biophysical assay results from these screening campaigns led us to conclude that we could be mor...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Christopher Fotsch, Debaleena Basu, Ryan Case, Qing Chen, Pratibha C. Koneru, Mei-Chu Lo, Rachel Ngo, Pooja Sharma, Amit Vaish, Xiang Yi, Stephan G. Zech, Peter Hodder
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2024-06-01
סדרה:	SLAS Discovery
נושאים:	Hit characterization Hit quality Hit triaging Target engagement
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S2472555224000212
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